Doxy PEP Offers Alternative To Condoms

[Your Man in Arlington]

On 8/26/2023 at 7:44 PM, LookingAround said:

I’m on Apretude (the shot).  Anyone else on it?

I'm currently on Truvada just to get started out, but plan on switching. Seems like a winner if you can swing 6 visits per year vs 4.

[+ Tygerscent]

On 7/29/2023 at 1:30 PM, Simon Suraci said:

From what I’ve read, it sounds promising and worth more studies to corroborate data to make a case for widespread use.

I wonder how the potential for mass long term use of various antibiotics may accelerate the development and spread of antibiotic resistant strains of STIs.

If/when the antibiotics we have now are no longer effective against those problematic strains, and those strains are circulating much more commonly through the population (especially among MSM), what then will we have available to fight infections?

Wouldn’t it be nice if we could eradicate all STIs? …*sigh* 

I‘m with you here… There are already resistant variants of both Syphilis and Gonorrhea~ There’s also been a shortage of antibiotics globally~   
  Eventually, antivirals and antibiotics give way to resistant variants similar to the way weed, insects and fungi evolve around pesticides, herbicides and fungicides~   
 It would almost make sense if the diseases they were trying to prevent were in small localized populations but, STI’s are global and  can leap between species, (herpes, syphilis, Chlamydia, Human Paloma Virus, autoimmune viruse… for example: Atlantic bottlenose dolphins can contract HPV, Baboons can contract herpes, rabbits can contract syphilis, Chlamydia affects sheep, goats, cats, to a lesser degree cattle, llamas, deer, Guinea pigs and mice~). So, there are always reservoirs of unprotected populations. 
 Coronavirus has been around a long time and has affected other species. When it found us, we were naive to it and now have this ongoing  situation~   
 If we create super bugs that other species can get, (ultimately becoming Petri dishes for microbe mutation and potentially increased virulence), that may present a concern for other species and again, come back into the human population at some point… especially since human beings come in contact with these other species,( on a global level). 
 I’m not aware of any antiviral or antibiotic that has not been the subject of a resistant form of the pathogens they were treating, (including HIV and Herpes).  Viruses tend to take residence in a bodily reservoir~ Then they resurface when conditions are optimal for replication~  
 There’s always going to be human error on administration and adherence to prophylactic and disease management treatments~  
 There is also the process of nature that allows living organisms survive life stresses and certain threats~   
 As long as the “cure” rate is below 100%, there will remain a resistance potential~ 

 

On 7/29/2023 at 1:30 PM, Simon Suraci said:

From what I’ve read, it sounds promising and worth more studies to corroborate data to make a case for widespread use.

I wonder how the potential for mass long term use of various antibiotics may accelerate the development and spread of antibiotic resistant strains of STIs.

If/when the antibiotics we have now are no longer effective against those problematic strains, and those strains are circulating much more commonly through the population (especially among MSM), what then will we have available to fight infections?

Wouldn’t it be nice if we could eradicate all STIs? …*sigh* 

 

[+ Tygerscent]

On 7/30/2023 at 4:49 AM, pubic_assistance said:

Deterioration of kidney function in men over 50 is his major concern.

The stomach issues are more uncomfortable than dangerous.

Some liver damage reported but not common.

DESCOVY appears (thus far) to have fewer incidents than Truvada.

Also worthy of mention: medication to pharmaceutical drugs, do you have impressive lists of side effects that are either potential or probable. They even make drugs to treat the side effects and drugs to treat the side effects of the drugs retreating the side effects. 
 My experience has shown me that people tend to think of the side effects of a particular drug that they are taking but don’t consider the side effects and interactions between the various drugs. They may be taking at the same time. They also don’t take any consideration, that some of the side effects and compounds can interact and cause other melodies when included with things like food, coloring, preservatives, various compounds in herbal teas and spices… What a good example of that is grapefruit juice~   
 What do you read about tests regarding the safety of sodium nitrate and its potential for cancer, the tests are basically based on administering excessive doses of sodium nitrate to lab specimens, and may be comparing them to the incidence rate of cancer in human beings~   
 So, there may be a suggestion for people to reduce her intake of sodium nitrates~  People don’t realize what the sources of sodium nitrate actually are. It can be in canned foods, it can be in their breakfast meat, their lunch meat, their dinner, meat, meat products that are in foods, but not easily identifiable, or obvious. They don’t consider that all of these suitable amounts of sodium nitrate consume during the day connect will be above a safe level for individuals who are susceptible to cancer from that compound~   
 Other chemicals that they take in process their daily lives, like fluoride in toothpaste, sulfur compounds, and preservatives of food, synergistic vehicles like salts and acids might change the toxicity of these compounds. 
The idea of throwing in antibiotics on top of the binders and fillers within them on some daily basis, with other things in your body, like insulin or antihypertensive drugs, or antianxiety drugs, or whatever… I don’t know… I have my reservations about the efficacy and safety of this sort of thing over time. 
 I think about how many countries and situations like war, poverty, limited surpluses that allow, and utilize expired or intermittent use of antibiotics because that’s all that’s available. It’s not like STI‘s or other diseases avoid those places because the antibiotics are old. Pathogens don’t care. It’s their opportunity to evolve around them 

Edited October 24, 2023 by Tygerscent

[+ Tygerscent]

On 7/29/2023 at 10:41 AM, TruthBTold said:

It looks as if they are beginning to study the possibility of not wearing condoms during sex and not worrying totally about acquiring STDs.  They are (at least in the Lancet) still worrying about some unintended side effects.  We shall see.  And I am interpreting it to mean this is why the non-condom wearer is either on PrEP or on 2-1-1 PrEP.  Here's hoping.

https://www.washingtonpost.com/health/2023/07/24/doxypep-std-sti-prevention/

 

It’s not that I don’t want this idea to work and I’m not saying it’s right or wrong, good or evil… I’m suggesting that the idea to me has some life realities beyond the “good sound” and “hopes of it” that may bring consequences that oppose the goal of containing and/or preventing the diseases in the populations,  (obvious or less so), they are targeting initially~ 

Edited October 24, 2023 by Tygerscent

[+ Tygerscent]

I was just reading g an article about shingles breakthrough in the 30’s 49’s age group…  
 It’s on the uprise in that age group population~     
 My wonder is, if somehow those getting vaccinated for shingles are getting mild cases of it, but, also carrying and spreading a variance form of it, not realizing that they actually have shingles. And some variance displaying symptoms in that younger age group is becoming stronger, more virulent and/or more communicable 

[LookingAround]

Tygerscent seems like you have a lot of somatic worries. 

 

[+ FrankR]

54 minutes ago, LookingAround said:

Tygerscent seems like you have a lot of somatic worries. 

 

That is your conclusion? I was thinking “he reads and he is smart/thoughtful about this topic”. No need to be intimidated. 

[LookingAround]

9 hours ago, FrankR said:

That is your conclusion? I was thinking “he reads and he is smart/thoughtful about this topic”. No need to be intimidated. 

I wasn’t intimidated. Tbh I was being judgmental  lol

[CuriousByNature]

On 10/24/2023 at 1:31 PM, Tygerscent said:

I was just reading g an article about shingles breakthrough in the 30’s 49’s age group…  
 It’s on the uprise in that age group population~     
 My wonder is, if somehow those getting vaccinated for shingles are getting mild cases of it, but, also carrying and spreading a variance form of it, not realizing that they actually have shingles. And some variance displaying symptoms in that younger age group is becoming stronger, more virulent and/or more communicable 

I could be wrong, but I don't believe a person can spread shingles.  I haven't had it, but my former neighbour did.  I used to do his grocery shopping, and my doctor told me that I couldn't catch anything from him because I had already had chicken pox.  Perhaps I am mistaken, but my understanding is that someone with shingles can transmit the infection as chicken pox to those who have never had it before, but that you only develop shingles when the old chicken pox virus is reactivated as shingles later on - normally when a person's immune system is stressed.  That neighbour ultimately had shingles two times before getting the vaccination.  

Edited October 31, 2023 by CuriousByNature

[Your Man in Arlington]

53 minutes ago, CuriousByNature said:

I could be wrong, but I don't believe a person can spread shingles.  I haven't had it, but my former neighbour did.  I used to do his grocery shopping, and my doctor told me that I couldn't catch anything from him because I had already had chicken pox.

I unfortunately had shingles in my 30's and this is correct, it's not contagious. Unfortunately, all of us who've had chicken pox are at risk.

I got my shingles vaccine when I turned 50; and, as unpleasant as it was, it was nothing like actually having shingles.

[+ BenjaminNicholas]

1 hour ago, CuriousByNature said:

I could be wrong, but I don't believe a person can spread shingles.  I haven't had it, but my former neighbour did.  I used to do his grocery shopping, and my doctor told me that I couldn't catch anything from him because I had already had chicken pox.  Perhaps I am mistaken, but my understanding is that someone with shingles can transmit the infection as chicken pox to those who have never had it before, but that you only develop shingles when the old chicken pox virus is reactivated as shingles later on - normally when a person's immune system is stressed.  That neighbour ultimately had shingles two times before getting the vaccination.  

Singles cannot be transmitted.

You can spread chickenpox, even as an adult.

There are vaccinations for both.  Easy to circumvent.

[KeepItReal]

20 minutes ago, BenjaminNicholas said:

Singles cannot be transmitted.

Are you sure? Singles behavior look contagious to me! 😆

[+ nycman]

7 hours ago, Your Man in Arlington said:

I unfortunately had shingles in my 30's and this is correct, it's not contagious.

That’s not 100% correct. 

The virus (Varicella zoster virus "VZV") that causes shingles is the same virus that causes chicken pox. If you get chicken pox as a kid the virus continues to "live" in your nerves forever. Most of the time the body keeps the virus "in check" and you are without symptoms. Every now and then, usually when your immune system is weakened (e.g. aging), the virus will escape and you’ll experience the flair as "shingles". 

During the shingles "flair" the virus is extremely contagious. It’s just that the vast majority of adults around you are immune (either from having chick pox as a child or having received the chick pox vaccine). Someone who has had neither chicken pox nor the vaccine, could contract the virus from someone with shingles.

Also, people who are severely immunocompromised (e.g. end stage HIV) are at risk of contracting the virus (even if they had chicken and/or were vaccinated) and developing symptoms. 

So yes, shingles is contagious. It’s just that 99% of the time it’s irrelevant. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722564/#:~:text=Shingles is very contagious.,secretions or their skin rash.

"Shingles is very contagious. You can catch chickenpox from someone with shingles through contact with their secretions or their skin rash."

Edited October 31, 2023 by nycman
Making it look pretty and updating the terminology

[mike carey]

8 hours ago, BenjaminNicholas said:

There are vaccinations for both.  Easy to circumvent.

Good reminder, in general, and specifically for me. From today over 65s in this country are eligible for the new shingles vaccine free (paid by the national pharmaceutical benefits scheme).

[Luv2play]

8 hours ago, BenjaminNicholas said:

Singles cannot be transmitted.

You can spread chickenpox, even as an adult.

There are vaccinations for both.  Easy to circumvent.

Actually there are rare cases and my younger sister was one where her chickenpox vaccine as a child did not take. I and my two brothers all got the vax.  

My sister developed a case of shingles and chickenpox simultaneously about 10 years ago in her 60s. It was very painful and affected her entire torso. Her doctor told her it was one for the medical books! 

[CuriousByNature]

4 minutes ago, Luv2play said:

Actually there are rare cases and my younger sister was one where her chickenpox vaccine as a child did not take. I and my two brothers all got the vax.  

My sister developed a case of shingles and chickenpox simultaneously about 10 years ago in her 60s. It was very painful and affected her entire torso. Her doctor told her it was one for the medical books! 

Now that I've hit 50 I'm planning to get the shingrix vaccine. 2 doses about 3 months apart. I know some people can experience pain for months or even years from shingles, so I'd like to avoid that if possible - or reduce the effects at least.

[+ nycman]

1 hour ago, CuriousByNature said:

Now that I've hit 50 I'm planning to get the shingrix vaccine. 2 doses about 3 months apart. I know some people can experience pain for months or even years from shingles, so I'd like to avoid that if possible - or reduce the effects at least.

You are a smart man. 

[marylander1940]

On 10/24/2023 at 10:52 AM, Your Man in Arlington said:

My doctor gave me a Doxy PEP prescription, and disclosed that he uses it as well. He did mention that if you're having frequent exposure periods (eg. 7 days a week), he doesn't recommend taking an antibiotic daily. My exposures are far enough in between that it I feel the added protection is worth it. In fact, due to my current schedule, I've only used on once so far and didn't experience any of the negative digestive side effects that he warned me of.

Agreed!

DoxyPep is good for clients but not so much for escorts who are BB pretty much every day, even if they have  day of the week without clients is not a good idea for them to take antibiotics on a daily basis

Please remember to have yogurt with probiotics and avoid alcohol the day you take 200mg of doxycycline or whatever pill he prescribed you 😉!

[+ sniper]

On 10/31/2023 at 7:38 PM, Luv2play said:

Actually there are rare cases and my younger sister was one where her chickenpox vaccine as a child did not take. I and my two brothers all got the vax.  

My sister developed a case of shingles and chickenpox simultaneously about 10 years ago in her 60s. It was very painful and affected her entire torso. Her doctor told her it was one for the medical books! 

Are you talking about 2 different sisters? Someone in her 70s couldn't have gotten a chickenpox vaccine as a child as it wasn't developed until the 1980s...

[+ sniper]

On 10/24/2023 at 10:53 AM, Your Man in Arlington said:

I'm currently on Truvada just to get started out, but plan on switching. Seems like a winner if you can swing 6 visits per year vs 4.

A friend got the shot and had a bad flu like reaction to it, felt sick for weeks. 

[SirBillybob]

10 hours ago, sniper said:

A friend got the shot and had a bad flu like reaction to it, felt sick for weeks. 

Oral lead-in dosing might have been appropriate.

https://medinfo.gsk.com/5f95dbd7-245e-4e65-9f36-1a99e28e5bba/e28f393c-fec0-4746-bd45-df61388fe935/e28f393c-fec0-4746-bd45-df61388fe935_viewable_rendition__v.pdf?medcommid=MED--US-9176#:~:text=When used for oral lead,directly to the initiation injections.

[SirBillybob]

On 10/31/2023 at 10:54 PM, marylander1940 said:

Please remember to have yogurt with probiotics and avoid alcohol the day you take 200mg of doxycycline or whatever pill he prescribed you 😉!

Though structure any dairy intake a few hours before or after popping the pill.

[SirBillybob]

On 10/31/2023 at 7:38 PM, Luv2play said:

Actually there are rare cases and my younger sister was one where her chickenpox vaccine as a child did not take. I and my two brothers all got the vax.  

My sister developed a case of shingles and chickenpox simultaneously about 10 years ago in her 60s. It was very painful and affected her entire torso. Her doctor told her it was one for the medical books! 

We seniors all had chickenpox; very few evaded it and the four of you were a household Petri dish. It is highly unlikely she caught chickenpox as a senior from one of the 400 or so Canadians currently getting it each year. Yes, a reactivation such that both clinical entities present simultaneously is certainly rare, more common among older folks with co-morbidity (eg, diabetes). 

[marylander1940]

14 minutes ago, SirBillybob said:

Though structure any dairy intake a few hours before or after popping the pill.

Probiotics are always good while taking antibiotics 

[Your Man in Arlington]

On 11/4/2023 at 11:11 AM, SirBillybob said:

On 10/31/2023 at 10:54 PM, marylander1940 said:

Please remember to have yogurt with probiotics and avoid alcohol the day you take 200mg of doxycycline or whatever pill he prescribed you 😉!

Though structure any dairy intake a few hours before or after popping the pill.

More details on what not to eat 2 hours before and after Doxycycline here:

Doxycycline and Dairy: Can Milk, Yogurt Affect This Antibiotic?

WWW.HEALTHLINE.COM

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Dairy products like milk, cheese, and yogurt contain calcium. When calcium comes into contact with doxycycline, it triggers a chemical reaction that can...