SirBillybob

As long as he accepts cheeks bouncing on him. 

As long as he accepts cheeks bouncing on him. 

Just temporary signage as negotiated with the movie production company, among other external set alterations. Subbing for 1987 San Diego Gaslamp Quarter.

As long as he accepts cheeks bouncing on him. 

As long as he accepts cheeks bouncing on him. 

Just temporary signage as negotiated with the movie production company, among other external set alterations. Subbing for 1987 San Diego Gaslamp Quarter.

Binged Ripley on Netflix yesterday and today. 8 episodes. Couldn’t stop, but nice way to wait out a nasty Spring snowstorm in front of the fireplace. Some Fargo-like elements added for humour, one in particular very funny.
If you can get past Flynn at age 41 and Scott at age 47, though. Law and Damon were late 20’s. I don’t know how much Ripley ages thru Highsmith’s sequels. I do believe the plan is further adaptation. 

Was there ever a "good" time?……grin

Re: thread merging. Thanks for inserting the year-old topic. I had been aware of it. I consciously started the new topic as it is specific to the one bacterial STI [gonorrhea] most concerning for its increasing standard treatment failure rate, as well as adds vaccination concepts (eg, Bexsero) not included in the previous discussion but that had been referenced in at least one other thread on the board. Moreover, the previous topic discussion is antimicrobial resistance focused and requires unpacking the merits and liabilities of DoxyPEP alone across a broader range of viral and bacterial diseases. There are also several separate threads more relevant to gonorrhea alone over the past year, including vaccination as mentioned, newly emerging first-in-class oral treatment medications, and acute disseminated gonococcal disease. Anybody wishing a more integrative reading experience is advised to use the search term ‘gonorrhea’ on the board. 

My biggest concern at this point is for the speed at which the DoxyPREP regimen may accelerate the resistance of chlamydia and syphilis.
Obviously, it is a bit of a summary article and not a not a journal article on the research data, but I am gathering that while chlamydia remained relatively constant, starting at 88% with the initial DoxyPREP trial and 89% a year in, syphilis was initially 87% and fell to 79% a year in.
If the big picture observations are that:
- DoxyPREP only reduces gonorrhea infection rate by 33%;
-studies show evidence that vaccination with meningococcal B by itself reduce gonorrhea by 30 - 50%;
-current scientific theory tells us that short bursts of antibiotics contribute resistance;
-antibiotics take a toll on body systems; and
-we already know that Benzathine Penicillin G is already a better treatment for syphilis than doxycycline
I would place my faith in vaccination for gonorrhea, treat syphilis with the superior antibiotic, and treat both gonorrhea and chlamydia with a FULL course of Doxycycline as needed.
And of course, pray to the pharmaceutical and profit gods for vaccines specific for all three!

Re: thread merging. Thanks for inserting the year-old topic. I had been aware of it. I consciously started the new topic as it is specific to the one bacterial STI [gonorrhea] most concerning for its increasing standard treatment failure rate, as well as adds vaccination concepts (eg, Bexsero) not included in the previous discussion but that had been referenced in at least one other thread on the board. Moreover, the previous topic discussion is antimicrobial resistance focused and requires unpacking the merits and liabilities of DoxyPEP alone across a broader range of viral and bacterial diseases. There are also several separate threads more relevant to gonorrhea alone over the past year, including vaccination as mentioned, newly emerging first-in-class oral treatment medications, and acute disseminated gonococcal disease. Anybody wishing a more integrative reading experience is advised to use the search term ‘gonorrhea’ on the board. 

Re: thread merging. Thanks for inserting the year-old topic. I had been aware of it. I consciously started the new topic as it is specific to the one bacterial STI [gonorrhea] most concerning for its increasing standard treatment failure rate, as well as adds vaccination concepts (eg, Bexsero) not included in the previous discussion but that had been referenced in at least one other thread on the board. Moreover, the previous topic discussion is antimicrobial resistance focused and requires unpacking the merits and liabilities of DoxyPEP alone across a broader range of viral and bacterial diseases. There are also several separate threads more relevant to gonorrhea alone over the past year, including vaccination as mentioned, newly emerging first-in-class oral treatment medications, and acute disseminated gonococcal disease. Anybody wishing a more integrative reading experience is advised to use the search term ‘gonorrhea’ on the board. 

Yes.

Updated/revised DoxyVAC trial results a year later; reduced benefit from DoxyPEP and negligible benefit from Bexsero vaccine.
https://www.poz.com/article/meningococcal-vaccine-significantly-reduce-gonorrhea-risk

Or 99% are evolved and fit the profile of a customer capable of satisfaction with the 50-Euro-a-pop brothel playbook. Sexually mature and flexible homophiles equally open to insertive and receptive pleasure, not hampered by constrictive specifications, unencumbered by puerile notions of sexual position hierarchy. Trading off choice, perhaps optimal standards and preference, for convenience and the general life benefits of adaptation.
The average new parent will quickly realize that their toddler is a douche, insufficiently developed to be successfully cajoled regarding its laundry list. The best approach is to simply convey that you get what you get and you don’t get upset. 

Updated/revised DoxyVAC trial results a year later; reduced benefit from DoxyPEP and negligible benefit from Bexsero vaccine.
https://www.poz.com/article/meningococcal-vaccine-significantly-reduce-gonorrhea-risk

Nobody older than 40 would be caught dead in mine, or alive.

A close second.

My good times over the past 10 yrs 2 months, from point of starting up the ‘hobby’, have been:
RANKED
Rio de Janeiro about 2 dozen times amounting to several total months across all seasons
Barcelona about 10 times, Spring or Fall
Zürich, 3 times, Spring 
São Paulo about a dozen times across all seasons, amounting to a few months in total
Bogotá, 4 times, all seasons
Madrid merely once but a very lucky single once-in-lifetime find only a block from lodgings
Belo Horizonte, once, Dec, amazing single find
Medellín, once, Fall, a good single find
——
non-RANKED
Salvador Bahia, 3 times
Santo Domingo, twice
Mexico City, twice
Recife, once 
Porto Alegre, once
Fortaleza, once 
Lisbon, once
—-
All told, very good experiences.

Or 99% are evolved and fit the profile of a customer capable of satisfaction with the 50-Euro-a-pop brothel playbook. Sexually mature and flexible homophiles equally open to insertive and receptive pleasure, not hampered by constrictive specifications, unencumbered by puerile notions of sexual position hierarchy. Trading off choice, perhaps optimal standards and preference, for convenience and the general life benefits of adaptation.
The average new parent will quickly realize that their toddler is a douche, insufficiently developed to be successfully cajoled regarding its laundry list. The best approach is to simply convey that you get what you get and you don’t get upset. 

Or 99% are evolved and fit the profile of a customer capable of satisfaction with the 50-Euro-a-pop brothel playbook. Sexually mature and flexible homophiles equally open to insertive and receptive pleasure, not hampered by constrictive specifications, unencumbered by puerile notions of sexual position hierarchy. Trading off choice, perhaps optimal standards and preference, for convenience and the general life benefits of adaptation.
The average new parent will quickly realize that their toddler is a douche, insufficiently developed to be successfully cajoled regarding its laundry list. The best approach is to simply convey that you get what you get and you don’t get upset. 

Like-with-like vaccination mixing affects infection breakthrough attack rates. Obviously, if vaccinated person A has 80% reduction in infection risk then the risk to vaccinated person B similarly possessing the benefit of 80% efficacy is less than if A is unvaccinated and had had zero risk reduction at point of A-B contact. Same with HIV PrEP, etc.

Binged Ripley on Netflix yesterday and today. 8 episodes. Couldn’t stop, but nice way to wait out a nasty Spring snowstorm in front of the fireplace. Some Fargo-like elements added for humour, one in particular very funny.
If you can get past Flynn at age 41 and Scott at age 47, though. Law and Damon were late 20’s. I don’t know how much Ripley ages thru Highsmith’s sequels. I do believe the plan is further adaptation. 

Binged Ripley on Netflix yesterday and today. 8 episodes. Couldn’t stop, but nice way to wait out a nasty Spring snowstorm in front of the fireplace. Some Fargo-like elements added for humour, one in particular very funny.
If you can get past Flynn at age 41 and Scott at age 47, though. Law and Damon were late 20’s. I don’t know how much Ripley ages thru Highsmith’s sequels. I do believe the plan is further adaptation. 

I hope so, especially since the Fjord Probe was discontinued.