Will doxyPEP create antibiotic resistant STDs?

[SirBillybob]

On 9/29/2024 at 5:01 PM, Luv2play said:

I’ve read elsewhere in this thread that the Doxypep dosage of 200 mg should be taken 24 to 72 hours post potential exposure to an STI, not 12 to 24 hours as you stated. 
 

Also that if one has more than one sexual encounter in a weekend that the dosage of 200 mg of doxycycline should be taken Monday morning. 
 

Since that was the case for me this weekend, I will be taking my meds tomorrow morning with breakfast and avoid dairy products. 

I absolutely stated no “shoulds” about Doxy uptake. Rather, described ongoing research trial protocols that are methodologically correct regarding uptake timing. 

The bacterial STI medicinally applied prevention problem has not been cracked like some naïvely think. However, the horse has bolted from the pen through premature marketing (in fact, none at all by Merck Pharma). If you want to enter a rodeo that is thematically closer to an underground cock or dog fight than a health regulatory body consistently and globally supported intervention, detailed questions about uptake certainly apply. It’s not just off-label; the papyrus on which the monograph is prematurely written is insufficiently processed and dried.

As you can gather, I have a horse-cart cart-horse standard that needs to be satisfied. As a person older than 65, I’m already picky about curating my HIV PrEP uptake as it seems to be a well kept secret that tenofovir/ emtricitabine for HIV prevention is off-label for seniors, both daily and on-demand formats. 

Edited October 1, 2024 by SirBillybob

[SirBillybob]

On 9/28/2024 at 3:03 AM, SirBillybob said:

Obvi post-edit time limit a few days ago I meant emtricitabine, the mnemonic spelling cue directed more by trying to sit following a binge as opposed to a sinfully impossible attempt at bi. 

Edited October 1, 2024 by SirBillybob

[Luv2play]

This last weekend I had protected anal on Friday night and unprotected on Saturday night with two different providers.
The provider who wore a condom was not on Prep. The one who did not wear a condom was on Prep.
Unprotected oral for both. So I decided to take the doxypep on Sunday evening after dinner but before Monday morning. I guess I could have taken it Sunday lunch but I was on the road and ate at a restaurant. Sunday breakfast would have been less than 12 hours. 

Edited October 1, 2024 by Luv2play

[SirBillybob]

12 hours ago, Luv2play said:

This last weekend I had protected anal on Friday night and unprotected on Saturday night with two different providers.
The provider who wore a condom was not on Prep. The one who did not wear a condom was on Prep.
Unprotected oral for both. So I decided to take the doxypep on Sunday evening after dinner but before Monday morning. I guess I could have taken it Sunday lunch but I was on the road and ate at a restaurant. Sunday breakfast would have been less than 12 hours. 

The point is that you could have been colouring within the lines even if taking the medication within the nutrition consumption window of a Papa Burger trio (sans fromage) at 03:00 on Sunday in the event of late night munchies a few hours following the last risk exposure.

Again, the minimum 12-hour lag from sex to après-sex prophylaxis in current research protocols simply deviates acceptably from the ‘ASAP within 72 hours’ guidance.

Similarly, there’d have been no reason to question the acceptability of dosing around Sunday breakfast rather than Sunday lunch.

However, if you had considered the 8 ounces of food, primarily protein, as having satisfied meal accompaniment guidelines and had popped Doxy an hour subsequent to Saturday evening encounters I’d have to say that would just be showing off.

Edited October 2, 2024 by SirBillybob

[marylander1940]

On 10/1/2024 at 6:53 PM, Luv2play said:

This last weekend I had protected anal on Friday night and unprotected on Saturday night with two different providers.
The provider who wore a condom was not on Prep. The one who did not wear a condom was on Prep.
Unprotected oral for both. So I decided to take the doxypep on Sunday evening after dinner but before Monday morning. I guess I could have taken it Sunday lunch but I was on the road and ate at a restaurant. Sunday breakfast would have been less than 12 hours. 

Remember to always have some yogurt when you take antibiotics.

[mike carey]

At last, some overdue culture in the debate!

[Luv2play]

33 minutes ago, marylander1940 said:

Remember to always have some yogurt when you take antibiotics.

I read that doxycycline should not be taken within two hours of eating dairy products, which would rule out most yogurts.

[MikeBiDude]

3 hours ago, marylander1940 said:

Remember to always have some yogurt when you take antibiotics.

You should double check your source on that…most antibiotics don’t go with dairy.

That said…neither of us are doctors, so listen to your doc and his advice.

[marylander1940]

6 hours ago, MikeBiDude said:

You should double check your source on that…most antibiotics don’t go with dairy.

That said…neither of us are doctors, so listen to your doc and his advice.

I should have been more specific

Yes, it's generally safe to take yogurt or probiotics while taking antibiotics: 

 

 

• Helps prevent diarrhea

  Probiotics can help reduce the risk of diarrhea by more than half when taken with antibiotics. 

   

   
• Rebalances gut bacteria

  Antibiotics can kill off some good bacteria in your body, so probiotics can help restore the balance. 

   

   
• Doesn't interfere with antibiotics

  Research suggests that probiotics don't interfere with how antibiotics work. 

   

   

Some recommend: 

 

 

• Eating yogurt or taking probiotics while taking antibiotics 
   
   
• Choosing probiotic strains like Lactobacillus rhamnosus GG and Saccharomyces boulardii 
   
   
• Spacing dairy products from antibiotics 
   
   
• Taking probiotic supplements 
   
   
• Eating other foods that contain prebiotics or probiotics, like sauerkraut and kimchi 

[marylander1940]

9 hours ago, Luv2play said:

I read that doxycycline should not be taken within two hours of eating dairy products, which would rule out most yogurts.

of course!

but right after some light food. 

[Luv2play]

8 hours ago, marylander1940 said:

I should have been more specific

Yes, it's generally safe to take yogurt or probiotics while taking antibiotics: 

 

 

• Helps prevent diarrhea

  Probiotics can help reduce the risk of diarrhea by more than half when taken with antibiotics. 

   

   
• Rebalances gut bacteria

  Antibiotics can kill off some good bacteria in your body, so probiotics can help restore the balance. 

   

   
• Doesn't interfere with antibiotics

  Research suggests that probiotics don't interfere with how antibiotics work. 

   

   

Some recommend: 

 

 

• Eating yogurt or taking probiotics while taking antibiotics 
   
   
• Choosing probiotic strains like Lactobacillus rhamnosus GG and Saccharomyces boulardii 
   
   
• Spacing dairy products from antibiotics 
   
   
• Taking probiotic supplements 
   
   
• Eating other foods that contain prebiotics or probiotics, like sauerkraut and kimchi 

These recs are conflicting. One says spacing dairy products and another eating yogurt. You can’t have it both ways.

[moonlight]

To be clear the calcium in dairy interferes with doxycycline's absorption. So space out consumption at least a couple hours. Also space out antacids/multivitamins with doxy.

[marylander1940]

11 hours ago, moonlight said:

To be clear the calcium in dairy interferes with doxycycline's absorption. So space out consumption at least a couple hours. Also space out antacids/multivitamins with doxy.

and with PrEP also, I know guys who stopped taking calcium pills because of that. 

 

[marylander1940]

17 hours ago, Luv2play said:

These recs are conflicting. One says spacing dairy products and another eating yogurt. You can’t have it both ways.

 

On 10/23/2024 at 1:39 AM, MikeBiDude said:

You should double check your source on that…most antibiotics don’t go with dairy.

That said…neither of us are doctors, so listen to your doc and his advice.

Back to subject: when I take antibiotics, I also take yogurt with probiotics, not precisely at the same time but within the day. I hope I was clear this time. Sorry about the previous confusion. 

[moonlight]

12 hours ago, marylander1940 said:

and with PrEP also, I know guys who stopped taking calcium pills because of that. 

 

I've never heard of that and can't find any evidence to support that. If anything it's probably good to take calcium/vitamin D with PrEP since that could help offset potential losses in bone density. No reason why those can't be taken at the same time as far as I can see.

[marylander1940]

23 minutes ago, moonlight said:

I've never heard of that and can't find any evidence to support that. If anything it's probably good to take calcium/vitamin D with PrEP since that could help offset potential losses in bone density. No reason why those can't be taken at the same time as far as I can see.

Taken at least 2-4 hours apart. We've talked about it on here many times. 

These guys get calcium from natural sources and stopped taking the pills. 

Edited October 25, 2024 by marylander1940
misspelling