SirBillybob

The International Antiviral Society -USA panel is accepting of the on-demand 2 pill 24 hours prior to RAI uptake standard based on the Ipergay study. I believe the reference is in JAMA and easily accessed. For intermittent semi-spontaneous anal intercourse, 7-day blood plasma loading is unrealistic for many fellows at a practical level. Postponing a rare fuck opp don't work that way. We tend to want it and to want it stat. And as mentioned, PrEP is not intended to replace condom use. I do consult my ID specialist and switched a year ago from the 7-day single dose to 24-hour pre-coital double dose, even though I always know 7 days or more ahead of time when sex is going to occur, and even though cost is a non-issue for me. Granted, I neither expect readers to follow my decision nor the advice of a physician not in their care cascade. If IAS-USA and CDC want to duke it out on behalf of American MSM, fine with me. I am neither American nor USA-centric. CDC guidelines, while reputable and respect-worthy, are not global guidelines.

Oh, right. Thanks. On demand PrEP was 86% more effective for drug (.9% infection over average 9 months, with acknowledgement among the 2 subjects they had stopped the pills) compared to placebo (6% infection rate; n = 14 infected). Essentially, PrEP taken properly was very effective.

Sorry, I do not know why you cannot find this info. NSAIDS add to the extreme workout that Truvada confers [sorry, should be "imposes", not confers] on our kidneys. My follow-up PrEP team at a top-drawer clinical research centre always says: remember, drink lots of water and do not take any Advil. Try googling 'truvada nsaids' and follow the trail.

Help me out, please. A poster wrote in these related PrEP threads quoting an 86% something-or-other. I was skimming, then could not find the post during a more detailed read. Where is that post? Was it removed? Please tell me the thread name and the date of that specific contribution.

Some of the confounders comparing daily versus demand related to the reduced distinction between the sexual patterns of the two groups. More frequent sex among some in the demand group amounted to up to an average of 25 doses per month. This is analogous to taking continuous PrEP substandardly in the context of a frequency of anal intercourse that would ordinarily call for the daily regimen. Therefore, a lot has to do with taking the chosen course appropriately ... not news. In contrast, in the substudy of demand PrEP compared to demand placebo, each group's average pill dose frequency was about 15 per month ... equivalent to about 3-4 sex cycles based on, give-or-take, two simultaneous pills before followed by one pill on each of two subsequent days.

Ibuprofen is contraindicated while taking Truvada. I switch to Acetaminophen or ASA for occasional headache use (unrelated to ARV meds) as needed during my on-demand PrEP cycles. Psyllium husk is food and is water soluble. There are no food adjustment requirements for tenofovir/emtricitabine. I do not alter my psyllium consumption when taking PrEP because it does not affect the pharmacokinetics/bioavailability of the drug. The most challenging requirement is increased water consumption for renal protection, because I have never felt particularly thirsty and I have an "urgent bladder". When taking PrEP I always need to be conscious of where I can pee if out doing some activity.

There is a lot of easily accessible research on comparing both the effectiveness, and MSM consumer reasons/preferences, for daily versus OnDemand/intermittent/pericoital PrEP. The guidelines for on-demand are a little more specific than the OP represented, based on his summary of his MD's description. This option is far more commonly utilized in Europe and Canada compared to USA. I take the on-demand course, though I have the same very low cost burden for either method. I think somebody mentioned donating their unused/stockpiled Truvada to a poz person that might be in need. NEVER make this call. Truvada is not used as a solo agent for HIV treatment. That is why routine testing is recommended for PrEP users. If seroconversion occurs, a different standard of medication is used for viral suppression and to prevent the complexities of drug resistance.

"George" is apparently now in HCMC Vietnam, while one of his escorting wingmen is in Melbourne. A very hot muscular 6'2" Mineiro workout buddy "Pedro" or "Pablo" or something like that, training with George end of April and posted on his IG feed, worked a shift recently at BCN Thermas, turning tricks for €50-70.

... and provide more photos, on request, of his visit to the dentist.

Still, the idea of a "controlled" prospective study is challenging. Randomized has been mentioned, but chaps interested in participating would already have been predisposed to douche or not douche based on preferential behavioral patterns. Douchers might grudgingingly agree to freestyle if scooped (against pre-established behaviour) into the residual-poop group but would possibly alter their receptive anal intercourse style. Also, when I started to try douching I did not like it and found it made no difference according to my needs and tolerances, so randomly imposing douching is fraught with complexity. Also, a point of clarification about double-blind. Assholes have eyes, so there would be no possibility of maintaining ignorance about the independent variable ... unless an anal douche is developed in suppository form with one a placebo version (here you may detect I am taking this to the ridiculous). The only possible visual impairment when I am getting royally shtooped is when my eyes roll back in my head or I am proverbially fucked blind. This discussion reminds me of the 1980's era when a mysterious syndrome emerged among queers and IVDU. Being gay was associated with thIs killer illness. Unique among gay men was a high preponderance of anal exposure to jizz. The 'retrospective' trends were enough to have me pause and alter my sexual behaviour. Others perhaps were sticklers about the disease manifestations and related presumed factors meeting all of the necessary and sufficient assumptions about causal directionality. Logically, I did not think that getting sick and dying made you a queer taking it up the arse. In contrast, without the need of a prospective design, I logically thought that being a queer taking it up the ass causally predicted morbidity and mortality. There may be 'just enough' evidence now about douching. Additionally, douching (or not) is non-stigmatized and either of them cannot be easily appropriated against us by the douche-y religious right in any way. Not douching also deflates pharma profit margins.

I am thinking a prospective research design, whether randomized or douche option- selective, would be tricky because each subject douching would need to be pair-matched with a nondouching participant on several variables unequivocally predictive of STI. Douche methods and AI style alone are already variant. In addition, STI is a broad categorical variable. The incidence of an arbitrary quantity of non-specific STI over an arbitrary time frame may not reveal much. Also, since history (duration) of douche practices seems to be related to rectal lining vulnerability, matched pairing would be limited in this respect.

I have seen more recent photos of this guy, depicting a more accurate representation and possibly higher age, compared to the ad pics. Though age 29 sounds about right. I found his IG profile and it is private, but google search brings up both some of the ad photos and less-in-shape photos. He is from or was based in Curitiba. The green eyes are genuine. I suggest before booking to ask for current images thru Whatsapp. He does seem to be bottom-heavy like a speedskater or cyclist. Less arm mass and tone. Anyway, you can simply google his escort name and access oodles of Brazilian escort sites where he has also added his IG name in some. This may be his first time out of country and on RM. Beyond endowment accuracy, the range of accessible images gives an idea.

Lister actor(ress) is lead in Netflix series Dr Foster, worth a peak as well. Anne/Jack's paternal spinster aunt, sister of her father (the old dude there) is the older woman at Shibden. The mother is dead. Anne/Jack had years before obtained co-ownership from her paternal uncle and this aunt (his sibling), the idea being that she would inherit fully. Her father (a third sibling in the older generation) and sister resided there without ownership claim.

... find it easy not to be maudlin when don't make it to the top.

I need a roofer with enough stamina to bang all day on top of me.

He posted a workout in Toronto yesterday. Since he did some modelling work in USA a while back, possible explanation is he did not honour the required visa category or duration.

I use words that exist in newspapers, mainstream magazines, etc. Surprisingly, perhaps, such publications also draw on vocabulary found in more academic material. My one misstep was thinking you might look up What You See Is All There Is, as I used the acronym form. Various impressions of the escort's character emerged from differences in initial encounters describing him and/or interaction with him. I was making a point about staying centered and objective in the face of polarized views. You are helping to make my point about bias. You likely have an impression about me that you might go to great lengths to defend. Your contribution may shape and reinforce others' impressions if they share your preferences for styles of written expression. It can be a struggle to roll back a point of view. I already admitted that I had a positive biased impression of this chap, but then two opposing descriptions of the escort demanded some mental work about choice. I do not proclaim to have particular skills in avoiding the tendency of bias myself. I think that the intense way in which you expressed disapproval reflects a need to gain approval in some way. I know I like acceptance myself. (This is universal, not a jibe attempt.) Illhelpya was evidently not attempting to start a war in which sides need to be taken. Discussing the dynamics of conflict in perspective is typically going to involve going deeper into ideas, at the risk of drawing on more complex language. Otherwise, it might end up a polarized fight to the death concerning whether the guy is A-list or A-hole. Failing to recognize blind spots, not acknowledging that what you see is not all there is, is the basis of most problems. I find this to be an uphill battle myself. I actually do, fairly quickly, make good enough judgements about hire choices. I think my own take on a guy is pretty independent of what might be predicted based on others' experience. Nevertheless, there is some comfort in accessing the 'skinny' on a prospect. I consider many factors but do not usually get tripped up weighing them. I suspect this holds true for all of us here.

The best ad messages are believable, legible in font type size and saturation, do not use complex language when simple is adequate, memorable (eg, ideas in verse, such as simple rhyme, are taken as more credible and insightful), name the product easy to pronounce (attention to logical correct upper/lower case; no symbols, only letters and numbers but only where digits create an associative response in memory !), with possible consideration to priming consumer action. Moreover, maybe contain partial ripoff components of other popular brand names in associative recall.. HiramHung123Go ... just an example, likely too long and silly. This is very impromptu. But Hiram is boozy denoting mellow, conveys anchored position 'here I am', whisky is macho, HH is alliterative, Hung primes Hunk associativeness, the starting pistol is athletic phallic charged explosive and alerts to temporal expediency while priming action over complacency. Hiram holds as legit abbreviation and some readers connect it to Walker, George to curious, Sam to Yosemite, Steven to even ... most conventional names evoke association, so make it a good one. Do not do what some cruel parents do, use a name that is more befitting a beloved pet, unless you want to deliberately create a milder meeker persona. Effort is aversive to consumers. Adding the complexity of a Russian Doll approach to layers of information is not enticing. It undermines the advantage of speed, clarity, conciseness, and a balanced judicious degree of embellishment. Giving directions and cues to the task of reading attention? "What now ... proof is needed that the first stage of content is true?" is the readers intuitive response. Do not make him need to identify with any complex justification, including the idea that a reserved private compartment of viewing offers more titillation. It rings defensive and overdone, like if I did not hook you at hello let me give you the real deal that I failed to demonstrate at the get go. In other words, use my posts as an example of what not to do in devising a grabby ad. The idea of imposing on the viewer extra steps to access a secondary cache of ad content is preposterous. Save that for direct communication or undressing later.

Grain of salt, me too. For everything, as suggested. The WYSIATI bias applies to all of us. I am reluctant to discredit somebody's good experience, in spite of individual impression. I was primed to admire this Brasileiro long ago based on photos, so a good report is easier to integrate. The two competing narratives create dissonance and conflict, but are not logically incompatible. The bar is understandably set higher in evidentiary terms for validating shadiness.

Yes, I can confirm that the two run in the same 'woof'-pack of about a half dozen Colombianos and are training together, perhaps sharing accommodations as well. I think he is cuter than 'Alejo' who is a slightly bulkier tractor. 'Davis' is a few inches taller. Question is: what can happen if they are new at this? Likely all pulling in cash to support their physique goals. Too bad an upcoming visit to NYC is not in the cards for me. These guys are top of their class in competition. BTW, I am just confirming their association. I don't release private details ... it's a matter of principle, neither here nor via PM. Some of us are always going to have more info played close to our chest.

Yes, I can confirm that the two run in the same 'woof'-pack of about a half dozen Colombianos and are training together, perhaps sharing accommodations as well. I think he is cuter than 'Alejo' who is a slightly bulkier tractor. 'Davis' is a few inches taller. Question is: what can happen if they are new at this? Likely all pulling in cash to support their physique goals. Too bad an upcoming visit to NYC is not in the cards for me. These guys are top of their class in competition. BTW, I am just confirming their association. I don't release private details ... it's a matter of principle, neither here nor via PM. Some of us are always going to have more info played close to our chest.

One ring-dingy ... we need an Ernestine type to do a skit on this. Yes, he's been a bottom since his high school production of Midsummer Night's Dream [snort]. No, he does not accept cheques but he is one [snort].

One ring-dingy ... we need an Ernestine type to do a skit on this. Yes, he's been a bottom since his high school production of Midsummer Night's Dream [snort]. No, he does not accept cheques but he is one [snort].