Yes, I first heard of PrEP around 2015. I have had allergic reactions or very uncommon side effects (in some cases delayed) to various medications, hence my reluctance to try a relatively new one.
I have also received yearly COVID and flu vaccines, and am still generally very pro-vaccine, but my reactions to the vaccines have consistently been worse than any time I have had the viruses themselves (yes, I am aware that that is the point of vaccines, but I am also including times I have had the flu before a vaccine). As for masks… masks are not meant to be worn 24/7; it is just not a natural way to breathe. Going straight from never having worn a mask to wearing an N95 all the time caused shortness of breath, skin irritation, headaches where the straps were, etc. I dabble in an industry where I’m acutely aware of these things, and I’m 99% sure that wearing a mask so much permanently impacted my lung capacity.