SirBillybob

Descovy is not generally subsidized by provincial or territory health care plans in Canada, for either treatment or prevention. Some jurisdictions will cover the cost based on ‘exceptional need’. I assume that may be related to pre-existing hep/neph or bone health issues. My TDF/FTC PrEP is relatively infrequent and exclusively on-demand. Otherwise, I might be inclined to investigate further.

I believe that the Pfizer/BioNTech participants will be tracked for another 2 years. I expect that long before that time the placebo arm will be unblinded as they should not be denied vaccination, and the vaxx arm will be unblinded and followed for durability of immunity (bio-markers + infection incidence). In general, I hope that in 2 years we will know more about the potential for vaccinated individuals to host, shed, transmit, acquire infection, as well as updated severity/mortality data that guides precaution standards. I bought masks, sanitizer, and commenced thinking about mitigation 9 months ago. It seems that the time has passed quickly. Unfortunately, there is a substantial gap on the continuum between the actually intrusive measures I find reasonably tolerable or adaptable versus the exposure risks (notwithstanding eventual vaccination) posed by my desire to squander a large amount of liquidated funds on trade.

I assume the manufacturer is TEVA if you are USA-based. Canada and other parts of the world have had the generic option for over 3 years. I don’I think I have ever taken Gilead’s Truvada because I commenced subsequent to Fall 2017, but I have had generic emtricitabine/tenofovir prescribed in Canada and filled using at least three (maybe four) manufacturers, I believe one time it was TEVA’s. In fact, there have been company switches made by the pharmacist for a ‘repeat refill’ within one distinct prescription iteration. There should be no difference and I have not noticed any. I expect that side effects have more individual person or contextual factor variation than manufacturer variation. I use it ‘on demand’ in South America where I have always tended to have GI upset such as travellers diarrhea anyway. A few times in Europe without diarrhea.

It is inferred that about 85 in placebo group (.44%) versus 9 in vaxx group (.046%) acquired SARS-CoV-2 infection and I am assuming this was exclusively over the initial 28-day period as one must use a common time frame for comparison. Since the 28-day period for some Phase 3 participants, I assume, ended months ago, it may be that there have been actually more than 94 infection cases to date because the 70 additional cases to make up 164 cases should be able to manifest fairly quickly if comparable to community infection rates. Again, I assume that there is a temporal stagger and that each analytic stage must equalize the duration from 1st dose. As time progresses, the between-subject temporal gap from 1st dose shrinks proportionally. One phenomenon that supports my assumption about the preliminary 28-day analysis is that the one-month infection rate in USA over any given 28 days since mid-summer seems comparable to the placebo group infection rate reported. I have not compared to one-month infection rates in the other 5 nation study locations, though USA, Brazil, and Argentina seem to have similar trajectories in total cases. The remaining are Germany, Turkey, and South Africa. It is unclear to me whether the 4,580 shortfall from subject volume target represents ongoing participants not yet at 28 days or some degree of dropout. The protocol is about 170 pages and I am not going to read it all ... I also do not have a pharm background. Severity of infection cases has not yet been reported. I have attempted to ‘drill down’ a bit but it seems ambiguous and I believe that only symptomatic cases are reflected in the 94 to date ... due to the logistics of regular testing for the virus and capturing all exposures, perhaps. Also, some participants with past documented novel coronavirus exposure are included in the study, another potential confounder. Once the threshold of 164 cases is achieved, assuming again about a 10:1 ratio of acquiring infection, I will be interested in how many of the anticipated 150 or thereabouts cases in the placebo group at that time has had severe or even lethal outcome. Because ICU-grade severity and also death are relatively small proportions of overall cases, you need much larger sample sizes and longer follow-up duration to assess the vaccine according to disease severity and mortality. Because I assume it would have been somewhat advantageous for Pfizer/BioNTech to recently report case severity or death among the placebo group (parenthetically ... or suppress the actuality of severity/mortality among the 9 estimated vaxx cases ... that would have been less likely as well as poor fortune for the company), I take it that the results may be seen as not particularly impressive clinically, but a good prospect to mitigate transmission. That seems fine, the ultimate goal being to reduce exposure for those that might not respond well to the vaccine or might otherwise be among the unfortunates that experience severity or death.

To attempt to answer the question, I was in Bogotá for the first time last September for a week, loved it, and had no problems with safety and security. My concern about Medellin today would be that it is one of Colombia’s epicentres of Covid-19 and the “department” Antioquia is trending these days at about 1/50 persons potentially Infectious carriers, adjusted for 2-week contagion period and for estimates of undiagnosed ‘under the radar’. The official reported rolling average is 32.8/100,000 daily new case incidence. If Antioquia were a nation unto itself it would rank about 12th globally in new cases. For good info on the pandemic and ‘new normal’ ... www.medellinguru.com In terms of flights, my thinking had been that if I were to go to Medellín I would not rule out transferring in Bogotá, particularly if options were good in terms of flight times, to fly to the city airport in Medellín (Olaya Herrera) as I understand the ride from the international airport in Antioquia is apparently harrowing.

Being treated like an ATM only works if insert - remove happens in a very rapid cycle.

What gets me is not knowing ahead of time certain vid content costs extra. I may be repeating what I’ve written before, but the companion or fronting Twitter teasers are often just as arousing and any one of any lengths of them repeats automatically. I have done 3 OF one-month purchases and rarely even looked at them following an initial scan-through. Maybe one or two self-JO while viewing. In contrast, tend to get fixated on a few Twitter vids and JO ... wash, rinse, repeat. Often guys with OF options. To me, close enough, unlike a regular film preview. Sometimes still pictures on one device with Twitter clip on another. But solo scenes work fine for me. I get that interactive or more x-rated vids are sometimes more likely on OF.

But I’ll wager he then wanted to ‘rip off’ your clothes ?

Amore ties more gauge cash flow if in the hole you have insufficient funds.

I don’t think that detail was in the article, a news outlet in Canada.

Apparently he is an American working in Thailand, was charged, detained, and released on bail.

Penicillin, Penis swollen ... let’s call the whole thing off.

In Brazil you can be charged and do time for insulting somebody, especially if it is one/sided, even if the content is essentially true. A heated reciprocal exchange is more tolerated. A defamation charge can be brought against you for outing a closeted guy that has homosexual experiences on the ‘down low’, or a ‘gay for pay’ provider. If he advertises, fine, if there is a site review component, also fine. But not a good idea to post photos and comments elsewhere in the public domain, particularly if you add the true identity or his identity can be uncovered. People might say, why would he draw more attention to himself? Don’t be daft. For face-saving if not extortion.

A Tripadvisor reviewer is being charged and / or sued for a negative review of a venue in Thailand. I have not bothered to dig into all the details because I don’t do specific online reviews of anything and I am busy. I don’t usually read reviews either. I just saw the headline in my news feed. I wonder if this will alter the landscape of free speech for input on travel experiences, etc. In the pandemic context I suppose a bad review is the death blow for tourism-related products.

I have only used the ‘on demand’ version 2 + 1 + 1 ... more +1s as needed for an extended length (ie, travelling for sexual activity). I think maybe initially one or two bottles of Truvada for that purpose. I think it’s about 2 years now. I have been taking it as generic for most of that time, tenofovir / emtricitabine. It will be a while until re-uptake for travel and I will explore options again. It will hinge on what my government insurance covers. One side effect I recall: hot sex in Spain, Switzerland, Colombia, Dominican Republic, Brazil. But still condom use for insertive or receptive anal. After 35 years, I find the latex pretty much associatively eroticized.

Today Quebec province is two-thirds of the way to its Spring peak, which happens to be the current USA 7-day rolling average. Meanwhile, Montreal (one of the 18 provincial health regions) is already about there, that is, the previous provincial peak and the total USA new COVID incidence. I think R reproduction is minimally 1.4 for the province, higher in Montreal and Quebec City ... at 1.5 R, 10 persons infect 15, 15 infect 22.5, 22.5 infect 34. Only 4 cycles to multiply the first 10 over 5-fold. Extra bad news if the cycles are shorter than typical contagion period.

Many more venues will go under and only the top 10% will continue to thrive financially. I am not in that sector but lucky to have a stable retirement income, well until they tax me to death to pay for the largesse of printing money lately, and nobody to rely on me financially.

Quebec dic Quebec did not learn from its own lousy example. We are surging back to our April/May crest and both Montreal as well as the provincial capital Quebec City commence red alert lockdown Oct 1st. Bars and restaurants closed for at least 28 days.

Quebec has reduced public gathering max numbers from 250 to 50. The probability of at least one COVID carrier, about 12% for a group of 50, approximates what that metric was a month ago for 250 persons. Since we have a five-fold increase in rolling case average compared to a month ago, all the revised mitigation does is condense exposure risk into a smaller group. No reason to expect the strategy will have much effect. Quebec still ranks third in cumulative mortality, behind Belgium and Peru. We need the ‘hammer’, not the ‘dance’. Australia’s Victoria State approach should figure into our guidance here.

I go to brothels all the time when in Brazil. When there I say “Hey, bro, lookin’ to make some quick cash here in the bro-thel ... Hey, brah, wanna make some fast coin here in the brah-thel?” Then we mix up some hot sweat, spit, and jizz into a tasty broth in the broth-el.

We have an uptick in cases that has shifted us from code green basic measures to code yellow, very quickly. However we are very possibly going to have code orange restrictions for small gatherings imposed ... 10 down to 6 allowable. As that is a code orange measure, where in that category bars are subject to closure, we are not far off the likelihood of that reality. The government is understandably very miffed that all the warnings about compliance have gone unheeded by a small minority that seems determined to crash the economy and welfare of the majority. We are at between 20-25 % our peak prevalence in early May which was disastrous.

Gotcha. More idyllic areas contain little sense of the heated aspects of sociopolitical factors. I have not intersected with visible symptoms of unrest in urban zones, notwithstanding some degree of awareness it exists and is exemplified in pockets of volatility ... out of sight, out of mind, like anywhere. Don’t drink the tea at a Siberian airport lounge lest you be unintended collateral damage. A discussion about the viability of travel due to domestic problems might better fit the Politics forum, or a thread other than a specific foreign variation of The Deli theme.

Not sure what changes you mean outside of the pandemic ripple effects. I have been going regularly for many years and the relative level of stability seems not to have changed much. Are you perhaps making a blanket judgement without experience on the ground there, on the one hand, or are you a familiar traveller there, on the other, and there are specific unique deteriorations compared to 1, 2, 3, 4, 5, etc years back that spur concern? Brazil is not for everyone but I think there may be some extant issues exacerbated by novel coronavirus, not so much separate problems that would substantially impact on tourism if one hypothetically transcends the pandemic reality. Otherwise, unrest you may detect from media reports is ‘same old same old’. The country cannot be beat if on your agenda is access to remarkable trade in structured settings. I was in tears having to cut my last extended trip short mid-March when my nation insisted on returning and self-isolating. I had just found a few top-drawer providers that exceeded the already good quality to be generally unearthed there. Within weeks Quebec’s pandemic reality had become one of the worst shit shows for CoV incidence and mortality in the world. Generally things are no better here than at any point I have been in various Brazil locations. The citizens as a whole there are among the highest globally in terms of receptive intentionality with respect to vaccine options in the pipeline. You will see me returning to Brazil much more enthusiastically than crossing the border a few miles from me.

Fauci had a bit of a bird when physicists weighed in on mitigation pertinent to viral aerobics and they erred on the side of greater caution. It is unrealistic to control all pop anxiety, to have 100% scientific consensus, and to bring all skeptics up to the middle ground or resolve people conflating noncompliance with self-efficacy. Fauci appears sane in many groups as they are often populated with nutters, but he is not the only rational kid on the block. He is not our physician lead where I live. But he is good at synthesizing at the basic important common denominators.

It is believed that outdoor pulmonary tuberculosis transmission is possible though much less likely due to dilution. Again, depends on distancing and exposure to clouds of aerobic bacilli. Homeless people with multiple vulnerabilities in close proximity may transmit outdoors if relatively clustered together.