It's possible you might develop a certain degree of tolerance for them so that you have to huff harder and longer and look for more potent bottles. You might develop a rash if you make contact with the nose, etc.
Mixing poppers with alcohol, blood pressure medicine, or ED meds like Viagra can be pretty risky, too.
If you're worried, you should do a little research. https://www.talktofrank.com/drug/poppers is a good place to start.