I own several Pelican Cases of various sizes. The Harbor Freight knockoff Apache cases would work too.
If I host, I like to throw my valuables and sensitive data into a Pelican case then run a steel cable around something that would require tools to move (like the piping under the sink.) and connect the case to the cable with a sturdy padlock.
If I visit rather than hosting, I do nearly the same, but I lock the cable to the child safety seat anchors in the hatchback of my SUV.
Someone with a set of boltcutters or other special tools could steal my stuff, but someone won’t be able to grab-and-go without tools.