no expert on the Coachella Valley here, but know a bit.....
do NOT stay in Desert Hot Springs....and don't go east of Palm Desert
some would say there's no specific gayborhood in the area - but, rather, that the entire area is the gayborhood!
I'd guess anywhere along 111 or just north of it, from downtown PS all the way to Palm Desert, would be ok, perhaps staying closer to PS than PD if there's a choice.....avoid the I-10 area - not really convenient as there are high-speed roads closer to the action (the towns) that easily whisk people (clients) around......come to think of it, Palm Desert may be too far east for some
if you're hosting, some of your clients may want the anonymity of one of the huge resorts....and others won't care......you may also want to see if clients can get to your room directly without a key card or other intervening security......
others may have better ideas.....