San Francisco is pretty gay-friendly all over. All depends on what your income bracket is and what you can afford there. SF is a condensed tightly packed city that sits on a peninsula, so not so nice areas are in close proximity of those nicer ones. The Castro is nice but not as gay as it used to be years ago. May people were forced to leave the city because of the cost of rent/real-estate, lack of work and rumor has it many went to Portland, OR. Many lesbians have moved to smaller communities in Florida and made up their own communities there. I would suggest doing a scouting trip or two before you decide to move there. It's not the place it used to be. ?