Truvada is cheaper, has almost a decade of use in PreP, has a statistical increase in bone loss in patients taking it. In one study all the fractures occurred in men without bone loss, so it doesn’t seem to be clinically relevant.
Descovy is more expensive, very little long term research, causes more weight gain and increases cholesterol, both of which are generally considered bad for your heart.
So hips, heart, wallet,.....pick your poison.
I’d pick Truvada and avoid the shinny new apple.