I realize this thread is very old, but let's be clear... the title of this thread gets it ALL WRONG. The opposite of "safe" is not "bare", it is "unsafe". Bare still means unsafe. Even with PrEP.
PrEP will protect you from HIV, but it doesn't give you any protection against sexually transmitted infections (STIs). Using a condom is the best way to prevent other STIs such as gonorrhea, chlamydia, herpes, and hepatitis C.