I've had more than one person ask:
"Do you have children?" as almost the first thing they say to me. In those situations, it sounds like they're trying to shortcut to see if I'm gay, or available, instead of getting to know me even for just a moment.
Same thing when someone asks right away before knowing anything at all about me, "Is your wife going to (be meeting you, going with you, doing something)?"
This happened once with a woman. That time, I just glared at her a moment and then looked away.