All I have to add to everything that has been said is my experience with opioids and NSAIDS prior to any of my surgeries. My pain had gotten so bad that I was desperate for relief and nothing was helping. So I decided to mix and match diff meds in various quantities above and beyond what was prescribed. The pain lessened slightly, but I noticed my eyesight was funky... My vision keep "flashing" and I had tons of floaters... I called and was speaking to my doctor about it and I blacked out in my kitchen.... As I was unresponsive but still had the doctor on the line, THEY called the EMT's and they also had my emergency contact numbers, so my neighbor let them in, and I was rushed to the hospital... After a battery of tests and brain scans, the diagnosis was that I was "over-medicated".... Once I withdrew from my medicinal "cocktails", my sight and everything went back to normal, although the crushing pain was still with me, I then just stuck to what was prescribed while waiting for my surgeries, a period longer than usual because I also had had 2 heart stents put in prior, and there is then a mandatory 6 month waiting period before any surgical procedure can be performed. My Golden years have been a bit "tarnished"....