I typically am looking for PNP specifically. It's definitely possible to do it intermittently but regularly and basically be normal the vast majority of the time. These days it does feel as if it takes a bigger toll on my body than when I was in my late twenties, and I have noticed that many of the more experienced PNP providers really look kind of rundown themselves, even if they're 30yo or so.
Frankly it's so hard to find, at least for me, there's really zero risk of long term dependence. It's just not possible to get regularly enough or in sufficient quantities. And you are very unlikely to overdose on it unless you do something like ingest or bump it, where you could end up taking in much more than you would if inhaling over time and controlling it.
But the reason for using it is that it obviously that it is an experience. It does change how things feel, for the most part in a positive way. The most amazing experiences I've had sexually have been on it.
But in general, yes, I would say it's not for everyone. The most important thing if you do choose to use is to do it somewhere safe, stay hydrated, brush your teeth, and try to eat whatever you can, even though you will have zero appetite and it will be actually quite unenjoyable and a chore to take every bite.