I started taking PrEP while under the care of a physician who treated me for other conditions (asthma being the primary condition) for fifteen years, so he knew me. He also knew that I followed my asthma treatment protocol, which requires using an inhaler twice a day that if skipped results in immediate effects including shortness of breath. While he would ask if I missed a dose, he knew I hadn't.
I've only seen my current physician for a little over a year and in that time he has implemented a PrEP clinic and first now has permanent staff. They do not know me and, frankly, have been just a bit heavy-handed on grilling me about whether I was certain that I took my Truvada every day. On my last visit the topic came up and I said something to the effect of "I know some people find it difficult to take a pill every day. I've been inhaler-dependent for twenty years and have missed one dose and the effect taught me the importance of adhering to a schedule." The guy asked if he could quote me. I might speak at their next PrEP orientation.
As you said, @Benjamin_Nicholas it ain't that hard!