Silicone and water are not miscible. Silicone lubes are mostly silicone(s). (the one I use is 2 types of silicone with a vitamin E stabilizer/preservative). Water based lubes are generally, a glycerin type compound(s)(which provides the lubrication) and water and stabilizers and maybe some other things(like skin emolliants, fragrance, preservatives,etc. Wet Original has 14 ingredients). I would think the silicone would be very stable - thats why it was used in implants. However, for the water based lubes, if they are emulsions rather than true solutions, if something else gets in and breaks the emulsion you will get cloudiness and separation. Even in solutions, additions to the solution make kick one of the original solutes out of solution resulting in the phenomenon you describe. I would try and ensure nothing other than the original content gets into the bottle for any lube. Steven is also correct that an extreme temp change could break an emulsion and sunlight(UV) can speed up degradation of oxidizable compounds. Once the emulsion is broken you probably can't get it back. You are correct to discard since it is unclear exactly what is going on. I've been using Swiss Navy Silicone for years and never had an issue. Unless you would take the pump off don't know how you would get anything extraneous into the bottle. The bottle is great in that the top locks; I had a mess with a leaky bottle a long time ago, and even though it was in a zip lock, it seemed to migrate out